Calculate the NLC50 value for a PAH or HAC using the Target Lipid Model (TLM)
Source:R/ptlm.R
nlc50.RdThis uses the equation and default values from McGrath et al. 2018.
Arguments
- chemical
The chemical (a HAC or PAH) of interest
- slope
The slope in Equation 1 in McGrath et al. 2018. The default value is -0.94, which is taken from Table 3 in McGrath et al. 2018. It is not recommended to adjust this without good justification.
- HC5
The 5th percentile of the SSD of critical body burdens predicted to be hazardous for no more than 5% of the species. Default value is 9.3 umol/g, which was calculated using Equation 3 in McGrath et al 2018. It is not recommended to adjust this without good justification.
- dc_pah
Chemical class correction (Δc) for PAHs, as reported in McGrath et al. 2018.
- dc_hac
Chemical class correction (Δc) for HACs, as reported in McGrath et al. 2021.
References
McGrath, J.A., Fanelli, C.J., Di Toro, D.M., Parkerton, T.F., Redman, A.D., Paumen, M.L., Comber, M., Eadsforth, C.V. and den Haan, K. (2018), Re-evaluation of target lipid model–derived HC5 predictions for hydrocarbons. Environ Toxicol Chem, 37: 1579-1593. https://doi.org/10.1002/etc.4100
McGrath, J., Getzinger, G., Redman, A.D., Edwards, M., Martin Aparicio, A. and Vaiopoulou, E. (2021), Application of the Target Lipid Model to Assess Toxicity of Heterocyclic Aromatic Compounds to Aquatic Organisms. Environ Toxicol Chem, 40: 3000-3009. https://doi.org/10.1002/etc.5194